I consistently crash on all indoor away missions.
 

Radeon 4890/Intel Q550. Newest Catalyst drivers.

Seriously crash on every indoor away mission, making it impossible to complete them.

Anyone else?

Yup yup. Big nasty crashes on a 5870/Q6600 system. Pretty much happens each time I activate any kind of ability that involves particle effects or the like. The dumps that it generates are also pretty impressive in size.

I also tend to crash a lot in the indoor ground missions. It only really happens when I get into combat, and I dunno if it's just my imagination or not but it also seems at its worst in cramped areas like narrow corridors.

Oddly enough the outdoor missions seem to work pretty well for me.

Core i5 750
Radeon 5770 w/ 9.12 driver
4GB RAM
Win 7 64-bit

Here as well. Near flawless in space, but crashes with alarming regularity on ground/interior missions.

Intel Core 2 Quad Q6600
Radeon 4770 w/ 9.12 Drivers
4 GB RAM
XP Pro 32-bit

I had similar crashes in closed beta with 9.10 drivers. Upgrading to 9.12 did not change the behavior or frequency. Upgrading other system drivers (sound, etc.) had no positive effect.