As always, try to use the latest version of wine (as alluded to in the previous posts in this thread).

• wine - 1.3.16 is currently stable (using the Windows XP platform) and has a few bugfixes not only for memory leaks but performance issues in the d3d engine. You may find the current patch notes (that do not include your distribution's specific patches) for the latest 'git' version of wine here.
  
  Note, you do have a second option here. If you find that your distribution has patches which diminish or alter the wine stability in a negative way, you can read the documentation and try to compile the latest version from git source. I'd recommend that you only use this option as a last resort. As an example, Gentoo's mousewarp patch caused weird behavior with 1.3.15 and 1.3.16 of wine for me - breaking my scroll wheel function in STO even though it worked fine outside of wine and prior to these versions. So, I went with the git version - it did not contain the patch that broke my functionality.
  
• Video drivers. ATI/AMD and Nvidia both have video drivers for Linux (though, Nvidia has the best support for FreeBSD, Solaris, and a few other UNIX flavors). Make certain you are using the latest 'stable' version supported by the manufacturer AND your distribution. Sometimes, the latest version supported by the vendor is not the latest stable version for your Linux distribution. When in doubt, check your distribution documentation. (As a matter of course, I tend to find Nvidia's beta drivers fairly more useful for my testing because I know how to debug issues and provide feedback to them. Most users not familiar with how to do this should stick to what is stable.)