If you want to farm Romulan Marks via space missions, they're unavoidable. They aren't difficult (even my Eng Excelsior chews through them), just nuisances. All the subsystem targeting garbage just postpones their demise and maybe throws off your alpha strike. Plus in Azure Nebula Rescue, waiting on that reboot costs you time and thus marks, meaning you have the run it yet again. Its like they know they can't beat you, so they're going to annoy you into submission. Not an entertaining fight.