I got also a lot of times game crash when i switch to desktop with ALT+TAB at different gameplay moments, eg. i set to fly my ship to some location and ALT+TAB to do some other things (eg. to check STO forum) and 90% of times i unable to back to game, game does show just black screen, play music and feeling like game working but just i see blank, black screen and if to wait a bit nothing happens..

So normally i kill it with task manager and run again... I think game has some problems with it and not tested in this way.

P.S. Windows Vista x64, HP pavilion DV7