I couldn't load "Price of Liberty" which is the mission right after you receive your first bridge officer. I would step on the transporter, load maybe 10% of the map, and the game would crash. I tried making new chars, adjusting my settings, rebooting, etc. Finally I uninstalled the game, and downloaded it again. That worked. So, if you're having a problem that you can't resolve, give it a try. The error I was getting was "Error Reading File". FYI, it saved my chars, so I didn't have to redo the first mission.