I have been playing the game for awhile now so far find the ship control layout easy to use and the same for character movement and combat with a small learning curve.
The graphcs are really awesome and alot has went into the whole character creation and am really impressed.
What I think is missing from the game though is which is an important part of star trek besides combat and exploration is for each character to grow and be defined by the choices each character makes which in turn can open up new dialog with some races and not others and can and will effect the outcome of each mission. Examples of this might be anything from negotiating or helping to resolve a treaty, on a first contact mission, establishing trade with another race, or just interaction with other races and non player characters.
I sure hope that this can be added in the future to an already great online game that has alot of potential.