I joined a Defend the Sector space combat today in the Phi sector, and for alot of the fight I was utterly incapable to fire any weapons. Autofire, manual fire, space bar fire. Nothing worked. Someone else in my same instance had the same problem.
I didn't bug it ingame because I was too busy trying to kill a horde of klingon ships, until I just quit the game in utter disgust for the night.