You should probably get your eyes checked if you have issues seeing your UI at 1.00 regardless of your resolution, and I mean that in a completely non-offensive way; I have bad eyesight and .80 works fine for me.
I have perfect vision, w/o glasses, but on the enemy ship buffs, I still have to do a lengthy study to differentiate between many of the different buffs/debuffs. Especially when they have 15+ buffs running and I need to sort out the relevant information in a fraction of a second.
It may also be a resolution issue? I'm running 1920x1080 on a 24" monitor. On my previous computer, running lower res (16somethingxsomething), but on a 22" screen, I never had to increase my HUD size.