Every time I fly into combat against the Borg, their beams make my instrumentation go haywire. What are the best defences against them and the best weapons to deploy when fighting the Borg? Also, what are the best BOFF skills?

Is this post serious?

What you mean with this? I have never encountered any sensor or targetting problems when fighting against Borg.

I think you mean the effect of the Borg Boarding Parties... This is cleared by Tactical Team

Borg Plasma Fire = Cleared by Hazard Emitters

Borg Tractor Beams = Countered by Polarize Hull or Attack Pattern Omega

Borg Shield Neutralizer = Countered by Hazard Emitters

Borg Tachyon Beam (which now the Cubes AND Spheres possess) = Countered by Shield Heals (EPtS, Sci Team, TSS, etc.)

-BRJ

The best weapons to use are any with the [Borg] suffix, but those are gotten from running STFs and spending Marks of Valor on (which are also gotten from STFs).

If you aren't high enough level to run STFs yet, then just use whatever weapons you normally use.

What's an STF, please?

STF = Special Task Force

These are 5-man missions that are in Gamma Orionis, facing the Borg. You need a group to complete them, and they are not issued to your character until reaching Rear Admiral Lower Half 5.

-BRJ