Well, it sort of had to get a refit before it was "lost". It was heavily damaged during Nemesis, so they repaired and refitted the ship before sending her off to her fate.
During Nemesis, the Enterprise E had 16 phaser arrays, 9 torpedo tubes, that neat skin tight shielding similar to what the Enterprise-A had (Which is essentially a giant replicator creating another skin of the ship just a few meters away from the actual hull) and the argo shuttle which was useless beyond reproach.
It had no special armor beyond the standard ablative armor that the Defiant and Lakota had, it had no special phaser arrays to find cloaked ships, no cannons, no cloak, no massive phaser lance, it had nothing super special about it. It was an assault craft with a ton of phasers, torps, and massive shield power. Honestly if it comes out with anything short of this, it'd be a kick in the nuts to the Enterprise-E. It's boff loadout should be similar to that of an escort, since it is an "assault" cruiser, you should have "assault" abilities. Not big wads of engineering powers and special science abilities.