If you are running BitDefender 2013, and are having trouble getting STO to run, uninstall BitDefender and try to run STO.
PerfectWorld tech and myself have been trying to figure out my problem for a few days. All other games would run, but load up slow. I thought I had the Launcher bug, when I tried to launch the game the launcher would not show up. I even re-installed my OS a few times. Now I am running Windows 8 RP, and using a trial of Norton 360 and everything is working.