My targeting will switch from one ship to another while firing. I've notice this happening in Alert when targeting the dreadnought ship. Sometimes my targeting flips to a weaker target even though my ship is pointed at the dreadnought. This has also happened where I am firing at a capital ship and my target flips to a smaller fighter.
In addition sometimes my targeting/weapons HUD lights up indicating that I can fire (I'm in range of a target), however when I click on the fire button nothing happens. I then have to click on a target to fire. Usually when I click fire on a lit target/weapons HUD my weapons fire at a target.
I've noticed this in general, except my target completely clears (without hitting any of my target keys) and I have to target all over. It gets really bad when there are large groups of enemies or during PvP. I did manage to catch a glimpse of a PvP ship turning blue (as if an ally) for a split second and being removed as a target. I often have to double tab my targeting keys to cycle targets. All this started about two months ago.