I'd been having success running this under 10.6.8 until last night. When I logged in there was a ~300MB patch that had to be installed. After doing so (not that I had a choice). The screen flickered for about 7 minutes while the STO logo was displayed, then the screen went black and the intro music started. After about a minute of intro music the mouse and keyboard became unresponsive and I had to hard-boot the computer.
There was a crash log associated with this but that may be more of a result of me having tried to kill the wineskin process from an ssh connection to avoid the hard reboot. The output is here: https://gist.github.com/5f7b1ee1b2346a45e904