I normally run with "astrometrics off" in sector space. It just strikes me as odd that I still see the gigantic "[INSERT NAME OF] SECTOR" signs as I approach the edge of a sector, even though the other graphics are hidden.
I've got my bridge officers to alert me when I'm about to cross into another sector. I don't really need giant neon signs in space to tell me the same thing. I would consider those to be part of the astrometrics display, so they can be hidden or displayed as well.