I've got STO and Ventrilo on both my desktop and laptop (Windows 8 Pro, 64-bit). For some reason, I cannot use the "push to talk" (bound to my right alt key) on my desktop, but can just fine with my laptop. I've had it that way before upgrading from Windows 7 64bit to Windows 8 64bit.
On my desktop I typically run STO in a window rather than full screen. However, I can't even PTT when the STO launcher is my selected window.
Anyone else run into this?
edit: And before anyone says it, I'm not going back to Windows 7 :p