I am having this exact same problem as I type this, I can refine dilithium on my Federation Engineer character, but I cannot refine dilithium on my Federation Tactical Character or on my Klingon Defense Force character.

i have this bug since january 5 and my diliyhium reserve was not at zero, no response from cs sor far

While I have no problems manually refining on my Fed main (nonzero balance) I have noticed the automatic refining fails a lot, or it refines zero, even if I hadn't refined manually that day, with lots of ore sitting around. I'm not the only one in my fleet with this problem too.

My KDF is an Orion "entertainer" that never leaves Drozana... so... no problems there.

Well, I finally got a response...

They know nothing.

Pretty frustrating, just keep filing tickets so they are aware that it affects enough people to merit attention.

Im also having the same problem i think and i just started playing this I complete a daily quest and my Dilithium Ore keeps coming up zero when i want to buy something.

From what I can tell this problem is caused by reaching your daily refining capacity. The 'you can refine [x amount] dilithium today' counter doesn't reset automatically. Instead, it resets when you refine dilithium for the first time each day. So, if you refine 8000 in one day, you get stuck with disabled 'refine' button and can't reset the counter ever again.

yep, here is another one

I too can't refine. It says that i've refined 8000 today and can't refine more.
It's been a week now.
****

I got response from support ... they are a bunch of ******* ...

Then i took the matters in my own hands.
I got two stations from which i log on. I observed the problem from one of them so desided to check if i log on on the second computer it'll be the same.
I t seems that i can refine dilithium from the second station/computer/client but not from the first one.
So i think this problem has someting to do with the client (locally). That said - a simple client reinstall should remedy the problem.