1. The Honor Harrington Universe by David Weber. "Would be some great strategic space combat in that"
2. Ace Benidict Universe by Jack McDevitt
3. As said by a few others I saw, The Commonwealth Universe created by Peter F. Hamilton
4. Robotech because I just love it.
5. Babylon 5
6. Firefly was great.
Oh and it would be great to see a Battletech or Shadowrun mmo.
Last year, RDM's Battlestar Galactica toppled Star Wars from the top of my list. I've watched the series through twice, and am just about to start it up a third time. I've come to have some, how should I say it, disagreements with the course Star Wars has taken lately, and BSG has been an outstanding alternative.