Well, XBOX 360 controllers can be used if you have a lot of spare time and patience so Id imagine yes... although Im not sure you can port PS3 controllers into a PC (As I dont actually have one I couldnt really say)
Also... please tell me that ISNT a Na'Vi toon your using lol
flying a escort with a joystick (ie xbox controller) is just more fun.
ever find that you hit battery+EVM and the ship moves very fast, well the xbox controller is your answer if you wan to keep the target in the crosshair.
dont worry about the number of button, here is easily enough button combo for all the function. ofc you will still need the mouse for stuff like inventory, but you can be hardcore and AHK the mouse cursor and button to the joypad.