This used to come up a lot. If I remember correctly, it was tied to running the game at a different resolution than the windows desktop resolution. Try matching the game res and the windows res and see if that fixes your problem.
The same thing happened to me, but I already had the game running at the same resolution as my desktop.
What's worse, now I can't even run the game long enough to change the graphics settings before it hangs. The launcher appears to work fine (I even forced a verify), but once in game there seems to be a fixed countdown to lockup. If I leave it at character select, it still hangs. If I hurry and log into a toon, it still hangs. If I back out to the in-game login screen and try to get to th options menu from there, it still hangs.
Is there anything else I can do or do I just have to wait for the next patch and cross my fingers?
EDIT: One more strange bit - if I get into the Captain's Table, I can still hear the background noise and other players accessing consoles even after my game stops responding.
and here's the Windows crash report (the game itself doesn't seem to know that anything's wrong)
A problem caused this program to stop interacting with Windows.
Problem Event Name: AppHangB1
Application Name: GameClient.exe
Application Version: 0.0.0.0
Application Timestamp: 4e13f5b5
Hang Signature: f8d0
Hang Type: 0
OS Version: 6.1.7601.2.1.0.256.1
Locale ID: 1033
Additional Hang Signature 1: f8d0f43c664b01ab7c37b27198f3c8e3
Additional Hang Signature 2: 2610
Additional Hang Signature 3: 2610af78695d9d6fcfc19c2fe9569dba
Additional Hang Signature 4: f8d0
Additional Hang Signature 5: f8d0f43c664b01ab7c37b27198f3c8e3
Additional Hang Signature 6: 2610
Additional Hang Signature 7: 2610af78695d9d6fcfc19c2fe9569dba
I don't use Xfire but i've got pretty much the same problem, i run windowed maximized, and if i minimize im fine but the second i try to restore, BOOM gameclient.exe crashes, started happening the minute season 4 released on tribble when i played that but holodeck could minimize no problem now that S4 is out i minimize and try and restore? crash...