If it works from different computers/ISPs, then it seems like the problem isn't with Cryptic, but with the ISPs, or somewhere in between. I'm not sure what Cryptic could do about this - it doesn't sound like it's anything on their end.
A couple of points.
This has been an issue since friday morning/late thursday night.
This issue is widespread, across not only several different ISP's but also several countries
All traffic for those affected is being stopped at or just after the 22.214.171.124 location
and finally, according to the STO calendar, on Thursday there was the season 4.1 update, which, for those of us in Australia would have been friday morning.
Though I'm glad it's back up now I'm still quite annoyed that all we got from the staff was practically silence. Really, not good enough guys, especially with an issue affecting as many people as it did.