I wish I had this thread back when I bought one when they were worth 4 mil ._. I also thoguht they got duct taped to your arm like a true prosthetic. It'd have made for great RP or something if it was like that, I think.
I'd say if equipped on a Borg captain or BO they shouldn't need to remodulate when fighting Borg.
Considering it is a Borg Weapon, the Borg should adapt to it just as easily as any other weapon if not faster. Of course, a bonus to damage and maybe additional abilities when used by Borg Captains and Boffs would make sense since they are able to interface with the weapon better.
That would be interesting, racial weapon synergy. Based on which race is using the weapon, additional bonuses or penalties are added. Humans are usually the jack of all trades master of none in many games so they could use all weapons with no bonus or penalty except for phasers and phaser rifles. Bat'leths can be used extremely well with Klingons, but some other races get a minor bonus with other races get a penalty. Of course, new types of weapons would need to be added.