I'm more interested in whether Trion will keep the game running if the show flops. They've certainly done their best to separate it where it counts (different location and will only begin to be influenced by series events after Season One is deemed a success or not).
The first season of Defiance has already been filmed, 13 episodes. The second season of Defiance is already in production. So, at the very least, we'll be getting two seasons. It looks like a hybrid of Farscape, Firefly, and some others.