One surprisingly cool feature of the interface was the option to show or hide the uniform when you are wearing combat armor. If you don't like the look of the armor you picked up just right click it and select hide. I also like how you right click and drag to remove an item/skill from your hotbar. This prevents you from misclicking it and removing it by accident while left clicking to activate. While most other MMO will let you move or autohide parts of the chat interface, in STO you can actually minimize the chat box. It even minimizes to a communicator badge and makes the appropriate sounds when you receive a message.
I would be very happy if we could hide the xp bar, minimap, quest list, and external shield indicators for friendly and or enemy ships.